Research updates
Lip Augmentation: What a Clinical Review Covers
A 2022 dental journal review covers lip anatomy, filler and surgical options, techniques and complications. A plain-language look at what it says and its limits.

A 2022 review in a dental clinics journal walks through lip anatomy, the main ways lips can be enhanced, how injections are done, and what can go wrong. It frames the lips as part of the whole smile rather than a separate feature. For patients, it is a helpful reminder that hyaluronic acid filler is the most common option, that results depend heavily on anatomy and technique, and that much of what is written about lip technique still rests on clinical experience rather than trials.
Why a dental journal?
Dentists are closely involved in smile design, and in some places they also provide facial injectables. The lips frame the teeth, so changes to one affect how the other looks. This review was written for that audience, but its overview is useful for anyone thinking about lip treatment. Our article on filler and dental work covers timing if you have both planned.
What the review covers
Anatomy
The authors describe the three zones of the lip: the skin, the red part (vermilion), and the moist inner lining. Key landmarks include the fine ridge at the lip border, the Cupid's bow and the philtral columns. Blood is supplied by the upper and lower lip arteries, which branch from the main facial artery. They note that deep injections in the upper lip near these vessels call for particular caution.
Materials
Hyaluronic acid filler is described as the most popular choice. It attracts water, rarely triggers immune reactions, and is chemically linked so it lasts longer in the body. A key advantage, not always emphasized, is that it can be dissolved with an enzyme if needed.
The review also covers two surgical options that use the patient's own tissue: fat transfer and strips of deeper skin (dermis) placed into the lip. These are described as longer-lasting but involve a donor site, more recovery and their own risks, such as infection and tissue loss, which are higher in smokers and people with diabetes. These are surgical procedures performed by surgeons, not injectable clinic treatments.
Techniques
The authors describe their own injection methods for adding volume, defining the border and treating thin or older lips, including small amounts per session and spacing sessions weeks apart. They recommend photographs at rest and in motion before treatment. They also describe a vertical-injection style popular on social media for a heart-shaped upper lip and note that previous filler is often dissolved first. These are the authors' preferences rather than proven standards.
Complications the review lists
Common, short-lived effects include bleeding, swelling, bruising, redness and tenderness. Lip injections can also trigger a cold sore in people who carry the virus. Lumps and asymmetry may be adjusted or dissolved. Our article on lip filler migration covers one longer-term concern.
The most serious complication described is blockage of a blood vessel, which can lead to tissue damage if not treated promptly. The review mentions several measures, including a topical medicine applied to the skin. It is worth knowing that other published guidance differs on some of these adjuncts, and the mainstay of treatment for hyaluronic acid filler remains prompt dissolving with hyaluronidase, as described in our article on vascular occlusion safety. The authors also note concern about untrained injectors as a growing source of problems.
How strong is this evidence?
This is a narrative review combined with the authors' own protocols. It is not a systematic review and does not pool data from trials. The authors acknowledge that the "best" filler for lips is still debated and that their recommendations draw largely on their own clinical experience. That makes it a reasonable teaching overview, but not proof that any one technique gives better or safer results.
The review also quotes a popular "golden ratio" for upper-to-lower lip size while noting that studies in some groups found people preferred a more equal ratio. Preferences differ by person and culture, so ratios are a starting point for discussion, not a target.
Setting realistic expectations
One theme running through the review is that lip treatment should fit the person, not a trend. Social media often shows dramatic changes, sometimes edited or filtered, that may not suit most faces or match what filler can safely achieve in one visit. Swelling in the first few days can also make lips look larger than the final result, which can be confusing if you are not expecting it.
A realistic conversation before treatment covers what can change, what cannot, how long recovery usually takes and what the result may look like as swelling settles. It should also include the option of waiting or doing less.
What it means for you
- Lip treatment is about proportion and shape as well as size, and should suit your teeth, smile and face.
- Hyaluronic acid filler is reversible, which matters if you change your mind or a problem occurs.
- Smaller amounts over more than one visit are a common, cautious approach.
- Tell your injector if you get cold sores, as preventive medication may be suggested.
- People who are pregnant or breastfeeding, have an active infection near the mouth, or have certain medical conditions should wait or avoid treatment.
Frequently asked questions
How long does lip filler last?
It varies with the product, the amount and the person. Lips are a moving area, so filler often lasts a shorter time there than in some other parts of the face.
Is fat transfer to the lips better than filler?
Not better or worse, just different. It is a surgical option with longer-lasting results for some people, but it involves surgery, recovery and less predictability, and it cannot be dissolved.
Should I have old filler dissolved before new treatment?
Sometimes. It depends on how the existing filler looks and feels and what you want to change. This is decided individually at consultation.
If you are curious about lip treatment, our lip filler guide gives more background, and HealthPark offers consultations to talk through whether treatment, a smaller step or no treatment suits you best.
Source
Ghasemi S, Akbari Z. Lip augmentation. Dental Clinics of North America, 2022. Read the study



