Hyaluronidase
Dissolve excess and migrated filler
Free 30-minute consultationNo obligationFees reviewed in writing first
- Physician-Led Care
- CPSNS-Licensed Physician
- 15+ Years in Medical Practice
- Fees Reviewed in Writing
- Sydney, Cape Breton
Hyaluronidase
Hyaluronidase is an enzyme that breaks down hyaluronic acid, a natural substance found in our bodies that gives our skin its elasticity and moisture. This enzyme derived from bee venom, has a range of medical and cosmetic uses, including as a treatment to dissolve unwanted dermal fillers.
At HealthPark Medical Aesthetics, we offer hyaluronidase treatments administered by Dr. Puppala.
Hyaluronidase is used as a treatment to dissolve hyaluronic acid dermal fillers that have been injected into the skin. The main indication for hyaluronidase is to correct unwanted or adverse effects that may occur after dermal filler injections. Some of the indications for hyaluronidase may include:
- Overfilling: When too much filler is injected into a specific area, it can lead to an unnatural appearance or an imbalance in facial features. Hyaluronidase can be used to dissolve excess filler and restore a more natural look.
- Nodules or bumps: Occasionally, dermal fillers can create small lumps or nodules under the skin, which can be unsightly or even uncomfortable. Hyaluronidase can be used to dissolve these lumps and smooth out the skin.
- Vascular occlusion: In rare cases, dermal fillers can inadvertently block small blood vessels, leading to tissue damage or even necrosis (death of tissue). Hyaluronidase can be used to break down the filler and restore blood flow to the affected area.
- Infection: If an infection occurs after dermal filler injections, hyaluronidase can be used to quickly dissolve the filler and allow for proper treatment of the infection.
- Allergic reaction: Although rare, some individuals may experience an allergic reaction to hyaluronic acid fillers. Hyaluronidase can be used to dissolve the filler and alleviate the allergic reaction.
In these cases, hyaluronidase can be used to dissolve the unwanted filler by breaking down the hyaluronic acid. The enzyme works quickly, typically within 24 to 48 hours, and the effects can be seen immediately.
At HealthPark Medical Aesthetics, our hyaluronidase treatment is administered by Dr. Puppala. During the treatment, Dr. Puppala will inject a small dose of the hyaluronidase enzyme into the forearm to check for allergies to the enzyme. If there is no allergy, then it is injected into the area of unwanted filler. The enzyme breaks down the hyaluronic acid, allowing the filler to be safely and effectively dissolved.
The treatment is typically quick, taking only a few minutes to administer. Patients may feel a slight stinging or burning sensation during the injection, but this is typically mild and short-lived.
One of the main benefits of hyaluronidase treatment is its ability to quickly and effectively dissolve unwanted dermal filler. This allows patients to achieve the desired results without having to wait for the filler to naturally dissipate or undergo a more invasive procedure.
As with any medical treatment, there are potential risks and side effects associated with hyaluronidase treatment. These can include:
- Allergic reaction: Some patients may experience an allergic reaction to the hyaluronidase enzyme. This is rare, but it is important to discuss any known allergies to bee stings with Dr. Puppala prior to treatment.
- Skin irritation: Some patients may experience redness, swelling, or itching at the injection site. These side effects are typically mild and resolve on their own within a few days.
- Infection: As with any injection, there is a small risk of infection. However, Dr. Puppala takes all necessary precautions to minimize this risk.
It is important for patients to discuss any potential risks or concerns with Dr. Puppala prior to treatment.
Hyaluronidase treatment is a safe and effective option for patients looking to dissolve unwanted dermal filler. At HealthPark Medical Aesthetics, Dr. Puppala, is dedicated to providing the best possible care to each of our patients. If you are considering hyaluronidase treatment or have any questions about the procedure, please don't hesitate to contact us today.
Frequently Asked Questions
What is hyaluronidase used for in medicine?
Hyaluronidase is commonly used in medicine as an adjuvant to improve the spread of other medications, such as local anesthetics or chemotherapy agents. It can also be used to treat complications associated with the use of certain dermal fillers.
How is hyaluronidase administered?
Hyaluronidase can be administered intravenously, subcutaneously, or intramuscularly. It can also be injected directly into the site of a dermal filler injection to dissolve the filler material.
What are the potential side effects of hyaluronidase?
Potential side effects of hyaluronidase include swelling, itching, redness, pain, and bruising at the site of injection. In rare cases, an allergic reaction may occur, which can lead to difficulty breathing or swelling of the face and throat.
Is hyaluronidase safe to use during pregnancy?
The safety of hyaluronidase use during pregnancy has not been established. Therefore, it should only be used during pregnancy if the benefits outweigh the potential risks.
Can hyaluronidase be used to treat all types of dermal fillers?
No, hyaluronidase is only effective in breaking down hyaluronic acid-based dermal fillers.
How long does it take for hyaluronidase to take effect?
The effects of hyaluronidase can be seen within minutes to hours after administration, depending on the route of administration and the specific indication for its use.
How long do the effects of hyaluronidase last?
The effects of hyaluronidase typically last several hours to days, depending on the dose and route of administration.
What are the contraindications for hyaluronidase use?
Hyaluronidase should not be used in patients with a known hypersensitivity to hyaluronidase (such as allergy to bee stings) or any of its components. It should also be used with caution in patients with a history of allergies, asthma, or other respiratory disorders.
Can hyaluronidase be used to reverse the effects of Botox or other neuromodulators?
No, hyaluronidase is not effective in reversing the effects of Botox or other neuromodulators.
Is hyaluronidase a controlled substance?
No, hyaluronidase is not a controlled substance and is readily available for use in medical settings.
What Our Patients Say
“Always a wonderful experience visiting Dr. Puppala. Booking is easy, staff are friendly, and they explain everything in depth. Professional, knowledgeable, and fun!”
N.B. · Google review
“The staff is so kind and the doctor explained everything. I had several treatments and loved them all. Highly recommend.”
C.E. · Google review
“I’ve had lip filler, Botox, and laser tightening. Always comfortable, always great results. Highly recommend!”
J.M. · Google review
Reviews derived from Google and relate to HealthPark Medical Aesthetics generally, not to any specific treatment. Names have been initialised to protect patient privacy. Individual results vary and are not guaranteed.
Start With a Complimentary Consultation
Thirty minutes, no obligation, and a clear, honest plan — with benefits, risks, costs and alternatives explained, so you can decide with confidence.
45 Weatherbee Rd, Suite 404A, Sydney, NS B1M 0A1 · Mon–Fri, 10 a.m.–5 p.m. · drpuppala@healthparkbotox.com
Results vary from person to person, and not every treatment is suitable for everyone. Cosmetic treatments are not insured by MSI. Dr. Puppala is not a certified specialist in dermatology or plastic surgery.
© 2026 HealthPark Aesthetics
